Lipom

Zuletzt aktualisiert: 2022-11-16

Autor(en): Anzengruber F., Navarini A.

ICD11: 2E80.0Z

Fettgewebsgeschwulst.

  • Gutartiger Tumor des subkutanen Fettgewebes
  • Bei multiplen Lipomen spricht man von Lipomatosen
    • Benigne symmetrische Lipomatose
  • Lipome können im Rahmen von Syndromen auftreten:
    • Gorlin-Goltz-Syndrom
    • Pringle-Bournevillesche Phakomatose
    • Wermer-Syndrom

Männer > Frauen.

Genetische Prädisposition.

  • Insbesondere an der oberen Extremität und an den Oberschenkel kommen elastische, gut abgrenzbare, prall-elastische, halbkugelige, subkutane Knoten vor. In manchen Fällen können diese auch in Musklen einwachsen
  • Diffuse schmerzhafte Lipome werden als Lipomatosis dolorosa bezeichnet

Klinsches Bild.

  1. Tobias N. DANLOS SYNDROME ASSOCIATED WITH CONGENITAL LIPOMATOSIS. Arch Dermatol 1934;30:540.
  2. Ross CM. Generalized Folded Skin With an Underlying Lipomatous Nevus. Arch Dermatol 1969;100:320.
  3. Enzinger FM, Harvey DA. Spindle cell lipoma. Cancer 1975;36:1852-9.
  4. Evans HL, Soule EH, Winkelmann RK. Atypical lipoma, atypical intramuscular lipoma, and well differentiated retroperitoneal liposarcoma.A reappraisal of 30 cases formerly classified as well differentiated liposarcoma. Cancer 1979;43:574-84.
  5. Klein JA. Diffuse Lipomatosis and Tuberous Sclerosis. Arch Dermatol 1986;122:1298.
  6. Leffell DJ, Braverman IM. Familial multiple lipomatosis. Journal of the American Academy of Dermatology 1986;15:275-9.
  7. Ruzicka T, Vieluf D, Landthaler M, Braun-Falco O. Benign symmetric lipomatosis Launois-Bensaude. Journal of the American Academy of Dermatology 1987;17:663-74.
  8. Weiss SW, Rao VK. Well-Differentiated Liposarcoma (Atypical Lipoma) of Deep Soft Tissue of the Extremities, Retroperitoneum, and Miscellaneous Sites. The American Journal of Surgical Pathology 1992;16:1051-8.
  9. Asher HR, Schoenberg Fejzo M, Tkachenko A, et al. Disruption of the architectural factor HMGI-C: DNA-binding AT hook motifs fused in lipomas to distinct transcriptional regulatory domains. Cell 1995;82:57-65.
  10. Hengel RL, Watts NB, Lennox JL. Benign symmetric lipomatosis associated with protease inhibitors. The Lancet 1997;350:1596.
  11. Sciot R, Akerman M, Cin PD, et al. Cytogenetic Analysis of Subcutaneous Angiolipoma: Further Evidence Supporting Its Difference from Ordinary Pure Lipomas. The American Journal of Surgical Pathology 1997;21:441-4.
  12. Mentzel T. Lipomatöse Tumoren der Haut und des Weichgewebes. Der Pathologe 2000;21:441-8.
  13. Nascimento A. Liposarcomas/atypical lipomatous tumors of the oral cavity: A clinicopathologic study of 23 cases. Annals of Diagnostic Pathology 2002;6:83-93.
  14. Harvell JD. Multiple spindle cell lipomas and dermatofibrosarcoma protuberans within a single patient: Evidence for a common neoplastic process of interstitial dendritic cells? Journal of the American Academy of Dermatology 2003;48:82-5.
  15. Karim RZ, McCarthy SW, Palmer AA, Bonar SF, Scolyer RA. Intramuscular dendritic fibromyxolipoma: Myxoid variant of spindle cell lipoma? Pathology International 2003;53:252-8.
  16. Matsushima N, Maeda M, Takeda K. Dermal spindle cell lipoma of the posterior neck: CT and MR findings. Eur Radiol 2003;13:L241-L2.
  17. Goto T, Motoi N, Motoi T, et al. Spindle cell lipoma of the knee: a case report. Journal of Orthopaedic Science 2004;9:86-9.
  18. Tard??o JC, Mart??n???Fragueiro LM. Angiomyxolipoma (Vascular Myxolipoma) of Subcutaneous Tissue. The American Journal of Dermatopathology 2004;26:222-4.
  19. Hunter AGW. Oculocerebrocutaneous and encephalocraniocutaneous lipomatosis syndromes: Blind men and an elephant or separate syndromes? Am J Med Genet 2006;140A:709-26.
  20. Ardinger HH, Horii KA, Begleiter ML. Expanding the phenotype of oculoectodermal syndrome: Possible relationship to encephalocraniocutaneous lipomatosis. Am J Med Genet 2007;143A:2959-62.
  21. Caux F, Plauchu H, Chibon F, et al. Segmental overgrowth, lipomatosis, arteriovenous malformation and epidermal nevus (SOLAMEN) syndrome is related to mosaic PTEN nullizygosity. Eur J Hum Genet 2007;15:767-73.
  22. Sapp JC, Turner JT, van de Kamp JM, van Dijk FS, Lowry RB, Biesecker LG. Newly delineated syndrome ofcongenitallipomatousovergrowth,vascular malformations, andepidermal nevi (CLOVE syndrome) in seven patients. Am J Med Genet 2007;143A:2944-58.
  23. Bissler JJ, McCormack FX, Young LR, et al. Sirolimus for Angiomyolipoma in Tuberous Sclerosis Complex or Lymphangioleiomyomatosis. New England Journal of Medicine 2008;358:140-51.
  24. Moog U. Encephalocraniocutaneous lipomatosis. Journal of Medical Genetics 2009;46:721-9.