Bowenoid papulosis

Last Updated: 2023-07-07

Author(s): Anzengruber F., Navarini A.

ICD11: -

1/17

  • Condylomata acuminata
  • Molluscum contagiosum
  • Squamous cell carcinoma of the skin (spinocellular carcinoma, SCC)
  • Lichen ruber planus
  • Seborrhoeic keratosis
  • Nevus cell nevus
  • Extramammary Paget's disease

Lloyd 1970

Subtype of condylomata plana. Carcinoma in situ caused by mostly HPV 16 or 18 (rarely also HPV 31-35, 39, 42, 48, 51-54).

Young patients mostly between 20-30 years old.

Pigmented, verrucous macules and papules. They appear a little lighter in the mucous membrane area.

  • Clinical image
  • Biopsy
  • PCR with HPV typing

Genitoanal and on the mucous membranes.

Hyperplastic epidermis, mitoses, dyskeratotic keratinocytes.

  • Transition to invasive squamous cell carcinoma is estimated at approximately 1%-2.6%
  • Patients are highly infectious, partners should be examined regularly
  • Frequent recurrences

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  2. Takayama A, Ishiguro N, Kawashima M. Coexistence of Bowenoid papulosis and Bowen's disease in a patient with systemic lupus erythematosus. J Dermatol 2012;39:646-9.
  3. Papadopoulos AJ, Schwartz RA, Lefkowitz A, Tinkle LL, Janniger CK, Lambert WC. Extragenital bowenoid papulosis associated with atypical human papillomavirus genotypes. J Cutan Med Surg 2002;6:117-21.
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  5. Deen K, Burdon-Jones D. Imiquimod in the treatment of penile intraepithelial neoplasia: An update. Australas J Dermatol 2016.
  6. Majores M, Bierhoff E. [Actinic keratosis, Bowen's disease, keratoacanthoma and squamous cell carcinoma of the skin]. Pathologe 2015;36:16-29.