Tuberculosis fungosa serpiginosa

Last Updated: 2023-07-07

Author(s): Anzengruber F., Navarini A.

ICD11: -

Therapy regimen:

The initial phase should last for 8 weeks/2 months. During this time, the majority of the bacteria are killed. In the subsequent phase of therapy (lasting for months), attempts are made to eliminate the remaining bacteria. Antituberculous therapy should be continued for at least 2 months after the skin is free of symptoms
The therapy should last individually between 12-24, but at least 6 months!

Induction phase (2 months):

Rifampicin p.o. 10 mg/kg bw/d
Isoniazide p.o. 5 mg/kg bw. (with Vit B 6)
Pyrazinamide p.o. 35 mg/ bw/ d if necessary combination with allopurinol!
Ethambutol p.o. 15 mg/kg bw/ d
A clear improvement can be seen in the vast majority of cases after 1 ½ months

Consolidation phase:

Rifampicin p.o. 10 mg/kg bw/d
Isoniazide p.o. 5 mg/kg bw. (with Vit B 6)
Ethambutol p.o. 15 mg/kg bw/d (can also be omitted if isoniazid resistance has been ruled out)
HIV patients: therapy must be given for ≥ 7 months. Ethambutol should be replaced by streptomycin p.o. 15-20 mg/kg bw/d (from > 60 y. max 750 mg) in case of additional therapy with NNRTIs
Moist, antiseptic compresses
Surgical ablation if necessary